How to use Dymista® (azelastine hydrochloride and fluticasone propionate) nasal spray, your seasonal nasal allergy medicine

Ask your doctor or nurse to show you how to use Dymista the right way. You can use the diagram below to remind you of their instructions. For more complete instructions, please refer to Patient Information in the Full Prescribing Information, which comes with your Dymista Nasal Spray. An adult should help a young child use Dymista.

Click on the chapters below, or scroll down to see the full diagram:

Dymista Bottle

  • Dust cap
  • Spray Pump
  • Spray pump tip
  • Shoulder of spray pump
  • bottle

Before you use Dymista

DYmista is for use in your nose only. Do not spray Dymista in your eyes.
Before you use Dymista Nasal Spray for the first time, you will need to prime the bottle.

  1. Before you prime the bottle shake it gently
  2. Remove the clear plastic cap from the spray pump tip of the bottle.
  3. Hold bottle upright with 2 fingers on the shoulders of the spray pump and your thumb on the bottom of the bottle
  4. Press upward with your thumb and release. Repeat pumping action.
  5. Once you see a fine mist, your Dymista Nasal Spray is ready to use.
  6. After initial priming, do not use a bottle of Dymista after 120 sprays. Keep track of the number of sprays you use. (Do not count any spays used to initially prime the bottle.)

How to use Dymista

An adult should help a young child use Dymista.

  1. Blow your nose to clear nostrils.
  2. Shake the bottle gently.
  3. Close 1 nostril with a finger and tilt head forward slightly. Do not tilt head back.
  4. Place spray pump tip 1/4 to 1/2 inch into your other nostril.
  5. Do not spray directly onto the nasal septum(the wall between your 2 nostrils).
  6. Keep bottle upright, pump once firmly.
  7. Repeat steps 3-6 with your other nostril.
  8. Wipe off tip. Replace dust cap.
  9. If you do not use your spray for 14 or more days, you'll need to prime the pump with 1 spray, or until you see a fine mist. If you do not see a fine must, clean the tip of the spray nozzle.


  1. Once a week, remove the dust cap. Gently pull upward on the spray pump to lift away from the bottle.
  2. Wash dust cap and spray pump in warm tap water.
  3. Allow to dry completely.

If spray pump is blocked

  • Remove spray pump unit as shown above
  • Soak in warm water.
  • After spray pump is unblocked, rinse with cold water.
  • Allow to dry.
  • Replace dust cap
  • Do not try to unblock spray pump with a sharp object. This can damage the spray pump and cause you to not get the right dose of medicine.

More IMPORTANT SAFETY INFORMATION (the following information applies to both DYMISTA and its Authorized Generic)

  • DYMISTA can cause sleepiness or drowsiness. Do not drive, operate machinery, or do anything that needs you to be alert until you know how DYMISTA affects you.
  • Do not drink alcohol or take any other medicines that may cause you to feel sleepy while using DYMISTA. It can increase your chances of having serious side effects.

DYMISTA may cause serious side effects including:

  • Sleepiness or drowsiness
  • Nasal Problems. Symptoms of nasal problems may include: crusting in the nose, nosebleeds, runny nose, hole in the cartilage between your nose (nasal septal perforation). A whistling sound when you breathe may be a symptom of nasal septal perforation.
  • Slow wound healing. You should not use DYMISTA until your nose has healed if you have a sore in your nose, if you have had surgery on your nose, or if your nose has been injured.
  • Thrush (Candida), a fungal infection in your nose and throat. Tell your healthcare provider if you have any redness or white colored patches in your nose or mouth.
  • Eye problems, such as glaucoma or cataracts. Some people may have eye problems, including glaucoma and cataracts. You should have regular eye exams when using DYMISTA.
  • Immune system problems and increased risk of infections. DYMISTA may cause problems with the way your immune system protects your body against infection and increase your risk of infection. Avoid contact with people who have contagious diseases such as chickenpox or measles while you use DYMISTA. Symptoms of infection may include: fever, aches or pains, chills, feeling tired.
  • Adrenal Insufficiency. Adrenal insufficiency is a condition in which the adrenal glands do not make enough steroid hormones. Symptoms of adrenal insufficiency may include: tiredness, weakness, nausea, vomiting, low blood pressure.
  • Slowed or delayed growth in children. A child’s growth should be checked regularly while using DYMISTA.

Call your healthcare provider or get medical help right away if you have symptoms of any of the serious side effects listed above.

  • The most common side effects of DYMISTA include: changes in taste, nosebleeds, and headache.
  • Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of DYMISTA.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. DYMISTA and other medicines may affect each other, causing side effects.

Especially tell your healthcare provider if you take:

  • Antifungal or anti-HIV medicines. Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.

Before using DYMISTA, tell your healthcare provider if you:

  • are pregnant or plan to become pregnant. It is not known if DYMISTA will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if DYMISTA passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while using DYMISTA.

APPROVED USES (the following information applies to both DYMISTA and its Authorized Generic)

DYMISTA is a prescription medicine used to treat symptoms of seasonal allergic rhinitis in people 6 years of age and older. DYMISTA may help to reduce your nasal symptoms including stuffy nose, runny nose, itching, and sneezing.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit or call 1-800-FDA-1088

Click here for Full Prescribing Information for DYMISTA
Click here for Full Prescribing Information for the Authorized Generic for DYMISTA

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